Tobacco endgame measures and their adaptation in selected European countries: A narrative review synthesis

Due to the continued detrimental effects of tobacco use, a growing number of countries are embracing the idea of tobacco endgame, meaning ending the tobacco epidemic instead of controlling it. This narrative review aims to synthesize and update the evidence from earlier scientific reviews on effective tobacco endgame measures, as well as to assess their integration to current national strategies among European countries with official tobacco endgame goals. The synthesis of the prior scientific literature found most evidence on product-focused and some evidence for supply-focused policies. Little evidence was detected for user- and institutional-focused measures. An update for the tobacco-free generation measure showed uncertainty in reducing smoking prevalence, especially for adolescents’ reactions to age-restrictive laws. All the countries that established a tobacco endgame strategy have included product standards in their measures, predominantly based on European Union regulations on conventional tobacco products, yet standards above this level and considering other products were also common. Cessation measures were given strong emphasis in strategies, yet none of the countries linked these to specific endgame measures. Despite commonly mentioning vulnerable groups, such as youth and pregnant women, adoption of measures to reduce tobacco use among these groups was scarce. Lastly, the decline in tobacco use seems to be modest, implying challenges in meeting the endgame goals. To meet these goals, European countries should reinforce the implementation of known effective tobacco control measures such as tax increases. Furthermore, new innovative strategies and measures to meet the objective of an endgame should be explored.


INTRODUCTION
Since 2005, key global tobacco control regulations have been harmonized through the entry into force of the WHO Framework Convention on Tobacco Control (WHO FCTC).While most focus has been on the implementation of the measures required and recommended in the WHO FCTC, recently, more attention has been given to Article 2.1, which encourages countries to implement measures beyond the treaty to provide ultimate protection of health.This aligns with the paradigm shift where countries are embracing the idea of tobacco endgame -meaning ending the tobacco epidemic instead of reducing and controlling it 1 .
Tobacco endgame is defined as aiming for a minimal level of tobacco use in the general population -preferably with a measurable goal in a clearly defined time frame 1 .Following the developments at the national level, a 'Tobacco-Free Generation' (TFG) goal was set for the EU member states in 2021 in Europe's Beating Cancer Plan 2 .This has been defined in practice as reaching <5% tobacco use prevalence by 2040 at the EU level.As the prevalence of smoking among adults in the EU was 23% in 2020 3 , reaching the target likely requires both stronger implementation of key regulations -WHO FCTC including the MPOWER 'best buys' -as well as implementation of innovative measures to reach tobacco endgame.
In the implementation roadmap of the EU Cancer Plan 4 , the TFG goal is addressed through foreseen revisions of key EU tobacco directives for product regulation, marketing, and taxation.Furthermore, the EU-funded Joint Action on Tobacco Control 2 (JATC2) project is expected to facilitate the implementation of tobacco control measures through enhanced collaboration between the European countries 5 .Work package 9 (WP9) of JATC2 specifically addresses the best practices to develop effective and comprehensive tobacco endgame strategies.This is done by identifying and assessing forward-looking tobacco control policies and tobacco endgame strategies for the European region, also considering the integration of cessation support to these, and exploring and promoting best practices in their development, implementation, and evaluation.The final deliverable of this WP is an online toolkit to support awareness raising and national actions, available through the www.jaotc.eu-websiteas of June 2024 6 .
The so-called harm reduction or harm modification measures, often promoted by the tobacco industry as alternatives for smoking 7 , such as the use of electronic cigarettes or heated tobacco products, have not been considered in WP9 as tobacco endgame measures should aim at ending the use of tobacco and other nicotine products.
The research questions and their sub-questions of this narrative review are as follows: 1.What is the current knowledge on the effectiveness of proposed tobacco endgame measures, and what are the research needs? 2. Among European countries with official tobacco endgame goals, how has 'endgame' been operationalized in their national strategies?How has the tobacco endgame been defined in these countries?Have tobacco endgame measures been included in the strategies?Has support for tobacco cessation been integrated into the strategies?Have vulnerable population groups been considered in the development, implementation, and evaluation of tobacco endgame goals?Is the progress toward the endgame goal evaluated?Are the countries progressing toward the endgame goal with the selected measures?
To facilitate the understanding of tobacco endgame strategies and the development of national goals, this narrative review aims, first, to synthesize and update the findings of earlier scientific reviews on the evidence of effective tobacco endgame measures and research needs.Second, it seeks to investigate the current situation in Europe, focusing on the content of the endgame strategies and adaptation of different measures in countries that have set an endgame goal.
A narrative review of the adopted endgame policies in European countries was conducted.A narrative review can include variety of studies with the aim of providing an overall summary, including interpretation and critique, of a certain topic 8 .

DEVELOPMENTS Synthesis of existing literature on the current knowledge on the effectiveness of proposed tobacco endgame measures and the research needs
The most recent comprehensive review on tobacco endgame by Puljević et al. 9 , was an update of a previous one by McDaniel et al. 1 and included 49 publications through a search on five databases (PubMed, CINHAL, SCOPUS, Web of Science, Embase) and the inclusion of additional reports from a Google search and expert opinion 9 .This review described endgame policies and identified endgame gaps and research priorities.Since the Puljević et al. 9 review refers to recently published articles (search up to 2021), an update was carried out only for feasible policies (i.e.TFG) for which there were evidence gaps, by applying the same search string in PubMed used by Puljević et al. 9 to an updated timeframe (see Supplementary file Material A for the search string).A policy was defined as feasible in Europe on the basis of an expert opinion in JATC2 WP9 on its possible advocacy and social acceptability.The literature on each policy measure was considered sufficient if more than five articles were identified on the topic.

Inclusion criteria for the European endgame countries
The second aim of this narrative review was to identify countries that adopted a tobacco endgame goal in Europe.An endgame country refers to a country that has defined an endgame goal aiming at a minimal level or no tobacco use in the population in an official governmental document.The focus was outlined on European countries, which corresponded with the definition of the target group of the JATC2.The initial search of governmental strategy documents and other publications, such as news pieces, on regulatory changes, indicating the existence of a tobacco endgame goal was conducted between August 2022 and January 2023 without restrictions on document publication dates.The search was appended during the writing of this study.The search was first done by one author and later confirmed by three other authors.Based on the search, ten countries were included in the analyses: Belgium, Finland, France, Ireland, the Netherlands, Norway, Slovenia, Sweden, and as part of the United Kingdom, England and Scotland.Most of the included policy documents were national, longterm tobacco control strategies; some of them included action plans or roadmaps, while some were broader public health strategies (the Netherlands, Norway) or integrated strategies of substance use/addiction policies (Sweden).The authority responsible for the enforcement of the strategy was usually the Ministry/ Department of Health, whereas some strategies described the responsibilities of other, mostly governmental organizations/departments (Belgium, Ireland, Sweden).In the Netherlands, the strategy enforcement was appointed by signing a multisectoral agreement including, for example, civil society and business communities, municipalities, and healthcare, welfare, and education sectors.While several policy documents included descriptions of funding (either currently effective or possibilities for future funding), fewer details of its allocation and sufficiency for the enforcement of the strategies were described.
The data on the existence of tobacco endgame goals and strategies were complemented as needed by information provided in the answers gathered with the JATC2 WP9 questionnaire on tobacco endgame strategies.The questionnaire was distributed to all the WHO FCTC focal points in the WHO European region from 15 September 2022 until 13 January 2023.The questionnaire is available as part of the project indicator compendium 6 .

Measures
Policies that have been identified to have the potential to achieve a tobacco endgame were selected and grouped into product, user, market/supply, and institutional structure-oriented tobacco control measures based on two earlier endgame reviews and syntheses 1,9 .In the JATC2 WP9, one task was to assess the integration of tobacco cessation support to tobacco endgame strategies.Therefore, it was also assessed whether smoking cessation measures were included in the strategy and whether they related to specific endgame measures.
After identifying the countries, a further search of policy documents, governmental websites, scientific articles, and media coverage, such as news, was conducted to assess what measures the countries had adopted to achieve the tobacco endgame goal.Texts in the local language were used with the help of digital translator services, as needed.WP9 partners in each country did the final check of the gathered information and the translation to ensure factuality.In the case of identification of previous endgame policy documents for a country, only the latest one was taken into consideration.However, in some cases (such as in England), the policy documents overlapped, yet were not mutually exclusive.In these cases, more than one policy document was reviewed.The country policy documents included are listed in Supplementary file Material B.

Evaluation plan and vulnerable populations
The countries were considered to have an evaluation plan if the strategy documents included concrete actions on how to evaluate or monitor the strategy implementation.The documents were also examined to determine whether vulnerable populations (e.g.children and people with low socio-economic positions) were considered in the strategy, for example, by mentioning how tobacco use affects different population groups.It was also assessed whether vulnerable populations are considered in the implementation of the strategy.

Prevalence of use
To get a comprehensive picture of the level of product use in the included countries, four authors selected the indicators that were utilized to describe smoking, tobacco, e-cigarette, and smokeless tobacco use.Indicators reported by the WHO were selected because of the comparability of the data.

A synthesis of existing scientific reviews on the effectiveness of proposed endgame measures
Tobacco endgame policies were grouped into four broad categories as aforementioned: productfocused, user-focused, market/supply-focused, and institutional structure-focused (Table 1) 1,9 .Based on aspects of policy implementation, the authors identified policies that reached an evidence synthesis, i.e. for which results from multiple empirical studies were identified, selected, and combined to draw conclusions 10 .Evidence synthesis was considered as an indicator of progression toward the translation of research evidence into policy 9 (Table 1).
The tobacco endgame policy with the most evidence was the product-focused policy on mandatory very low nicotine content (VLNC) standard, with 26 studies that addressed various aspects of the topic (policy 1, Table 1).The main goal of the policy is to create less-addictive products with the aim of reducing tobacco use.Although a VLNC standard is yet to be implemented in any country, the New Zealand government announced in 2021 that it will implement such a measure by 2025 (yet this and other tobacco endgame measures have been since repealed when the government changed) and the US FDA has also proposed such a measure.Despite VLNC being the most studied policy, there are still several evidence gaps.First, the feasibility of VLNC is unknown.Moreover, there is no evidence of its potential effects in terms of mental and physical health outcomes, possible transition to other tobacco or nicotine products or other substance use, and priority populations.Then, industry and illicit market responses are unknown.Finally, the threshold for developing dependence is currently unknown 9 .
Another product-focused policy is setting product standards that would make combustible tobacco products unappealing, such as raising the pH of cigarettes or banning menthol (policy 2, Table 1).This policy was studied in a narrative review, which presented various proposals to redesign cigarettes but reported evidence only on public support for the policy for banning menthol 1 .
Less evidence was identified for market-/supplyfocused policies.Increasing tobacco taxes, making tobacco products generally unaffordable (policy 8, Table 1), was analyzed in seven studies.The policy was proven to significantly reduce smoking.The main gap that makes this policy unfeasible is that increases in tax levels necessary to achieve endgame goals could be politically difficult to implement in a short time frame.However, the Australian Government succeeded in increasing tobacco prices from around 4 euros per 20 cigarette package in 2001 to around 24 euros in 2021 11 .Ending sales of tobacco products (implemented in two local USA government areas) were analyzed in two studies, which presented large gaps in its effectiveness in achieving endgame goals and with no feasibility studies conducted (policy 5, Table 1).Also, the socalled 'sinking-lid' policy, i.e. setting a regularly reducing quota on the volume of tobacco products manufactured or imported into a country (policy 6, Table 1), was analyzed in two simulation studies that explored its practical implementation in New Zealand and simulated gains in health and cost savings 12,13 .
Ten studies considered a policy of restricting tobacco retailing as part of an endgame strategy, with the aim to reduce both adolescent and adult smoking rates (policy 9, Table 1).This policy was implemented in Hungary, where the number of tobacco-selling shops was reduced from nearly forty thousand to a few thousand, and set as a government policy goal in Australia.However, there might be significant differences between countries in Europe; for example, in Italy, France, and Spain, selling tobacco is allowed only for tobacco-specific retailers, and opposition from the retail sector will not be negligible when adopting such a policy 14,15  2. Set product standards for nicotine products that make combustible tobacco products unappealing or removed from the market for exceeding toxicity thresholds.
No (1) • Evidence on public support for the policy for banning menthol.
• Tobacco industry responses, e.g.substituting banned constituents with other harmful ingredients.

Userfocused
3. Require consumers to obtain a purchaser's licence or medical prescription to purchase tobacco.
No (4) • Modelling population health impact of tobacco-free generation.
• Key legal and ethical issues of the tobacco-free generation.• The implementation of this policy alone in a simulation model is unlikely to achieve a 5% smoking prevalence in 10 years.• If combined with policies of denicotinization and retail outlet reduction, this policy could have major impacts on reducing inequities in health.• Indirect evidence on youth defiance; universal laws may be better perceived by adolescents; age-specific laws are perceived as a form of youth control.
• Policy effectiveness • Exact meaning of human rights articles within the sphere of public health.
• Empirical evidence on effectiveness in achieving tobacco endgame.
6. Set a regularly reducing quota on the volume of tobacco products manufactured or imported into a country ('sinking lid').

No (2)
• Simulation of implementation in New Zealand.• Simulated impact on health gain and cost saving.No evidence was found for several policy categories: the user-focused policy on requiring consumers to obtain a purchaser's license or medical prescription to purchase tobacco (policy 3, Table 1); the supply-focused policy on actions that reduce the commercial viability of tobacco companies (policy 7, Table 1); and the institutional structuredfocused policies on transferring management of tobacco supply to an agency with a mandate to phase out tobacco sales (policy 10, Table 1).Similarly, no evidence was found on performance-based regulation whereby tobacco companies are required to work to reduce smoking prevalence (policy 11, Table 1).
Finally, the user-focused policy for TFG (policy 4, Table 1) was considered in four studies reporting substantial population-level health improvements, even if the potential of achieving the endgame goal of minimal smoking prevalence is not necessarily achieved if implemented alone.A recent simulation study in New Zealand considered a combined package of denicotinization of retail tobacco, a 95% reduction in retail outlets, and TGF.The authors estimated it was associated with a large smoking prevalence reduction 16 .The policy was implemented in Balanga City Council (Philippines) in 2016 by banning the sale and use of all tobacco products for those born on or after 1 January 2000, thereby becoming the first in the world to embody the TFG idea 17 .Moreover, unsuccessful attempts at implementation were carried out in New Zealand using 2009 as the cut-off date 18 and in Australia, in the state of Tasmania 19 .In Tasmania, the policy was introduced into parliament, but it lapsed when parliament was prorogued in 2018, despite the high public support for this proposed legislation  20 .In 2021, the policy was adopted in Brookline City Council (USA), using again the 2000 cut-off 21 .A European Citizens' Initiative was presented in August 2022 to achieve a tobacco-free environment and the first European TFG by 2030 by advocating for ending the sale of tobacco and nicotine products to citizens born after 2010 22 .

An update of review on the policy regarding tobaccofree generation (TFG)
The update of scientific reviews specific to the TFG policy resulted in nine articles, two of which were already included in the 2022 scoping review 9 , and five that did not include substantive evidence synthesis [23][24][25][26][27] .Two studies thus resulted from the update 16,28 .
Berrick 28 collected indirect evidence on the relevance and implications of adolescent psychology for minimum-age laws.This report highlighted the uncertain efficacy of age-restrictive tobacco laws in reducing adolescent smoking prevalence, recalling a recent review 29 that noted the absence of studies evaluating the effects of an age-of-sale ban as distinct from other, simultaneously enacted policies.Additionally, uncertainty around minimum-age laws was due to the fact that they are advocated by tobacco industries that are well aware of adolescent psychology and their reaction to age-restricted laws.This is exemplified by three aspects.First, being that tobacco use is legal and thus safe for adults, then presumably, the real aim of the law could be considered as youth control rather than tobacco control.Second, reactance theory predicts that youth who are legally excluded from the product will find it more desirable.Finally, in the presence of underage laws, cigarettes become a symbol of the onset of maturity.Another aspect of indirect evidence about adolescent reactions to age-restrictive laws was given for laws concerning motorcycle helmets, with youth defiance of an age-restricted helmet law that disappeared when replaced by a universal law 30 .This supports studies of youths' reactions, which highlight that universal laws may be perceived by adolescents as intended for protective benefit, whereas age-specific laws signal authorities' desire for youth control.However, raising the age of sale to 21 years seems to have a positive impact on reducing smoking; Tobacco 21 laws reduced smoking rates of youths aged 18-20 years by 2.5 to 4 percentage points [31][32][33][34] .
The second study resulting from the review update is a simulation model with a hypothesized effect of reducing smoking initiation by 90% in 10 years from the implementation of the TFG in 2022 in New Zealand 16 .The study showed that a <5% smoking prevalence will not be achieved in 2040 by sex and ethnic group.If combined with VLNC policies and retail outlet reduction, the TFG policy would achieve a rapid reduction in smoking prevalence, mainly due to VLNC, and would reduce health inequity between Māori and non-Māori 16 .
Summarizing, studies resulting from the review update did not report evidence to support the law for reasons related to adolescent psychology and the limited effectiveness of the law in reducing prevalence if implemented alone.

Research needs
Further research is needed to improve estimates of the effectiveness of endgame policies that are small or poor for most interventions due to the lack of implementation.The quantitative examination of examples of implementation (even partial) would be useful 9 .Moreover, further studies are needed to evaluate the impact of endgame policies in vulnerable populations and in different countries and regions, such as low-income countries.These populations have notably high levels of smoking prevalence, being in a previous stage of the tobacco epidemic 35 compared to non-priority or high-income populations.There is little research on the feasibility and effectiveness of implementing endgame strategies at an early stage of the tobacco epidemic 9 .

National tobacco endgame definitions
Results considering endgame definitions and measures were obtained from the assessment of the policy documents, supplemented with WHO FCTC focal point questionnaire 6 if needed.There were different definitions of the selected endgame goals.Most countries have defined it by the prevalence of tobacco (or tobacco and nicotine) product use (Table 2).Other definitions were related to TFG or tobaccofree society (TFS).Some of the countries incorporated both prevalence and TFG or TFS definitions in their endgame objective (the Netherlands, Norway, England).Most of the countries included combustible tobacco in their endgame goals, while some countries, such as Finland, Norway, and Slovenia, also included other tobacco or nicotine products (excluding nicotine replacement therapy), such as electronic cigarettes, in their endgame goals.

Have tobacco endgame measures been included in the strategies? Has support for tobacco cessation been integrated into strategies? Tobacco endgame measures
All of the countries included some product standards in their endgame measures, which were commonly based on EU Tobacco Products Directive (TPD) 36 regulations and mainly referred to bans on characterizing flavors and additives.Some countries (Belgium, Finland, Norway, and Slovenia) also extended flavor bans to products other than cigarettes and roll-your-own tobacco regulated by the TPD.Plain packaging was adopted in all the countries except Sweden.Norway included warnings on individual cigarette sticks, and Scotland included pack inserts in their strategies.France was the only country that acknowledged the reduction of nicotine levels in cigarettes.England and Scotland included the possibility of restricting tobacco possibility of restricting tobacco sales by year born in their strategies, yet none of the countries, yet none of the countries included a license or prescription to purchase cigarettes in the strategies.Considering institutional structure-focused measures, none of the countries included transferring management of tobacco supply to an agency or required tobacco companies to meet smoking prevalence targets defined by the governmental tobacco control policy.
M a r k e t / s u p p l y -f o c u s e d m e a s u r e s w e r e infrequently included in the strategies.None of the country's strategies included measures to end the commercial retail sale of combustible tobacco, to reduce the quota of tobacco products manufactured or imported into the country, or to reduce the commercial viability of tobacco companies.Additionally, none of the strategies included tax increases to make tobacco products generally unaffordable, although conventional tax increases were commonly included (yet they did not specify the type of tax: ad valorem or specific excise tax).Some countries adopted taxation on new products such as e-cigarettes or snus (for example, Finland, Slovenia, and Sweden).Strategies of all the ten countries included measures to reduce tobacco availability, for example, by licensing or registry systems and banning sales in certain places (near schools, festivals, hospitals, etc.) or banning distance sales.For example, in the Netherlands, tobacco sales are going to be restricted gradually only to tobacco shops, which is already in place in France.

Integration of tobacco cessation support
All the countries included a number of different smoking cessation support measures in their strategies.Cessation support measures included, for example, increasing and developing the services, increasing the availability and affordability of cessation medicines (for example, in France, by reimbursing nicotine replacement therapy), and preparation (Ireland, Slovenia) or enhancing the implementation (Finland) of national care guidelines.Even though cessation measures were given strong emphasis in the strategies, none of the countries linked cessation measures to specific endgame measures.

Have vulnerable population groups been considered in the development, implementation, and evaluation of tobacco endgame goals?
All the countries at least mentioned vulnerable groups in their strategies, usually children, pregnant women, people experiencing mental illness, and smokers with low socio-economic position (Table 3).This was especially emphasized in Sweden, which also was, in addition to England, the only country considering people according to sexual orientation in their strategies.Even though vulnerable groups were commonly mentioned, only a few countries planned exact measures outside of smoking cessation support measures for these groups.In Scotland and France, there are explicit objectives for the prevalence reduction of smoking in groups with

Is the progress toward the endgame goal evaluated?
All the countries had some plans to evaluate the progress toward the endgame goal.However, the level of detail in the description of the evaluation plan varied.For some countries, holistic elements of the evaluation of public health policies were discussed (Norway), whereas other countries had a more detailed monitoring and evaluation plan (Scotland).
Other countries described regular assessments of the effects of the measures but with less detail (Finland, Sweden).

Are the countries progressing toward the endgame goal with the selected measures?
According to WHO, regular daily smoking rates differed between countries from 24% (France) to 7% (Norway) (Table 4, Panel C).It was estimated that the prevalence of current tobacco use will decrease from 2022 to 2025 in all the countries (Table 4, Panel A vs Panel B).For most of the included countries, the decline in tobacco use prevalence from 2022 to 2025 is estimated to be about 1-3 percentage points.E-cigarette use and smokeless tobacco use differed between countries (Table 4, Panel D, Panel E).E-cigarette use was most prevalent in the UK, Belgium, France, and Ireland, while smokeless tobacco use was the most prevalent in Norway and Sweden.Overall, it seems that current progress is not sufficient for countries to reach their endgame goals (prevalence <5%) in due time.

DISCUSSION
In this article, we reviewed the current knowledge on the effectiveness of proposed tobacco endgame measures and identified future research needs.We also examined how the endgame goal has been operationalized in the national strategies among European countries with official tobacco endgame goals.
Existing scientific reviews highlighted sufficient evidence (over 5 studies) on tobacco endgame policies of VLNC, increases in tobacco tax that make tobacco products generally unaffordable, and restrictions on tobacco retailers 1,9 .An update of the literature was carried out for the tobaccofree generation (TFG) policy, which then reached sufficient evidence that was set as more than 5 studies on the topic.
The VLNC policy was the most studied tobacco endgame policy.However, research is needed to estimate its feasibility, its potential effects on the use of other tobacco products and in terms of mental and physical health, responses of the tobacco industry and illicit market to this policy measure as well as the adequate nicotine threshold of the products to alleviate nicotine craving.Although compensatory smoking might occur when smoking VLNC cigarettes, studies imply this is not the case 37,38 .Compensation might be nicotine-dose dependent and decrease when nicotine content is substantially reduced, so possible compensation could be accounted for in cigarette design 37,38 .'Light' cigarettes were marketed by the tobacco industry as less harmful than non-light cigarettes due to the lower amount of tar, yet this allegation has been scientifically repelled 39 .It might be that the marketing of VLNC cigarettes by the tobacco industry could rely on similar aspects of reduced exposure to that of light cigarettes 39 .Indeed, studies imply that smokers have misperceptions considering the harmfulness of VLNC cigarettes 40,41 .Light cigarettes have been banned in the EU since 2001 42 .
The increase in tobacco taxes and the restriction of tobacco retailers resulted in effectively reducing smoking prevalence.However, there is evidence of gaps in price elasticity and feasibility of tobacco retailer restrictions in some European countries.For example, the estimates for price elasticity 43 should be reassessed in situations where the availability of a product is heavily restricted, and this should be done for different products and by different population subgroups.
Evidence on the TFG policy reported populationlevel improvements but also uncertainty as to whether the objective of the targeted maximum smoking prevalence can be achieved, especially for adolescents due to their reactions to age-restrictive laws.In addition to the literature review, recent studies in the USA demonstrate that Tobacco 21 laws are widely supported and have positive results regarding the reduction of smoking in young adults and adolescents 44,45 .However, the majority of these policies have not yet been implemented, and their impact has not been assessed in European countries with an adopted endgame strategy.The final result is a lack of evidence of their wanted and unwanted impacts on this target population.Further research is needed to improve estimates of the effectiveness of endgame policies.Furthermore, studies are needed to evaluate the impact of endgame policies, not only in European populations but also in populations in the early stage of the tobacco epidemic 35 .
There remains large uncertainty on the feasibility of tobacco endgame measures.There are also differences in what measures are being considered as tobacco endgame measures in relation to new tobacco and nicotine products.For example, McDaniel et al. 1 did not consider the implications of e-cigarettes for endgame purposes, justifying it with the challenge of assessing their role in different endgame scenarios.This is due to, for example, the controversy over these products' marketing and use, the lack of long-term research on their health effects, variability among the products, and the political dynamics of rapid acquisition of e-cigarette companies by cigarette companies.On the other hand, Puljević et al. 9 presented 'moving consumers to reduced risk products' as one endgame policy with multiple evidence syntheses (8 studies on the topic).There is no widely accepted definition of harm reduction yet in the endgame approach where the aim is to minimize the overall health harms, the harm reduction approach should reduce the risks for all the different population groups, not only for individuals in some groups (e.g.smokers) [46][47][48] .The actual effects of a shift from conventional cigarettes to alternative nicotine products are usually guided by behavioral tendencies that are difficult to control only with policy interventions 49 .For example, in Italy, despite the sudden increase in novel tobacco products after their introduction, the majority of smokers were still loyal to conventional cigarettes, and more than half of novel product users kept on smoking conventional cigarettes 50 .Similar results have been found elsewhere 51 .In JATC2 WP9, harm reduction policies have not been considered as tobacco endgame measures.
Ten European countries were identified as having an official endgame goal: Belgium, Finland, France, Ireland, The Netherlands, Norway, Slovenia, Sweden, England, and Scotland.Most of them had defined the goal by a specific prevalence of tobacco product use and/or objectives related to a TFG or tobacco-free society.Prevalence-related objectives were defined as a use level of 5% or less.Also, in non-European endgame countries, such as New Zealand, the objectives relate to these two measures.Similarly, one of the objectives of the European Beating Cancer Plan ('Tobacco-free Generation' with a prevalence of 5% or less in 2040) is in line with these objectives 2 .In some countries, the objective included, in addition to combustible tobacco use, also nicotine use.Considering the extensiveness of the endgame approach in the EU, most of the member states have yet to set an endgame goal overall.So, the countries included could be seen at the forefront of tobacco control, with the aim of ending the tobacco epidemic 1 .
According to the assessment of the national endgame policy documents, all included countries were rather similar considering the adopted measures.For example, all countries had adopted some product standards in their endgame measures, mainly bans on characterizing flavors and additives.These bans were usually based on the EU TPD 36 .A more detailed list of allowed ingredients in products could be considered as manufacturers have made efforts to circumvent the ban 52 .One recent example is given by the Netherlands' restrictive list of flavoring additives in e-liquids 53 .Tax increases were another commonly adopted measure in the endgame countries, yet adopted increases were modest in terms of a definition of an endgame measure that would be to increase them to make tobacco products generally unaffordable.Strategies to reduce tobacco availability, for example, by licensing systems and/ or banning sales in some places, were adopted in all included countries.Examples of banning sales in certain places, such as in supermarkets and gas stations in the Netherlands and France, would give valuable information on possible challenges for other countries to acknowledge when planning to implement such a measure.Notably, the measure Tob.Prev.Cessation 2024;10(April):18 https://doi.org/10.18332/tpc/186402with the most studies on VLNC was acknowledged only in France among the European endgame countries.The measures the countries had adopted included, based on an earlier classification 9 , all but institutional-focused measures.Additionally, national policy documents lacked considerations of future technological and cultural changes in societies and their possible effects on the endgame goal or adapted measures beyond discussion on new tobacco and nicotine products already on the market.
Overall, important evidence gaps remain on the feasibility of different endgame measures for European countries.Most of the prior evidence comes from other countries, such as the USA, and more research on the possible effects in European countries is warranted.It must be noted that part of the adaptation of regulations is based on the implementation of the EU TPD 36 .It seems TPD is successful in setting some standards on regulations for the member states, such as those relating to product standards (such as the menthol ban).However, presently, TPD is less capable of supporting countries adopting and implementing more advanced measures than required by the directive.The procedure of notification to the Commission about national measures is one example that might hinder the adaptation of advanced endgame measures at the national level.
All the reviewed endgame policy documents included some mentions of vulnerable groups.These mentions were related to smoking cessation as well as to other measures.Identified vulnerable groups were most commonly adolescents but also pregnant women and persons with low socioeconomic position or mental health problems.Certain vulnerable groups were, however, neglected by most documents (e.g.LGBTQ+).Disappointedly, practical actions related to vulnerable groups were uncommon, as only a few countries planned measures to reduce tobacco use, especially among these groups.Pro-equity measures should be emphasized when planning, adopting, and implementing future tobacco control measures to account for different population groups, especially those most vulnerable 54 .Smoking cessation measures were given strong emphasis in country strategies, but incorporating cessation measures in specific endgame measures was lacking.These measures could be linked to, for example, VLNC and high tax increases.In general, cessation support is one of the domains where European countries need to improve the implementation of measures laid down in Article 14 of the WHO FCTC 55 .
Countries had different plans for evaluating the progress toward the endgame objective.Some countries had a comprehensive evaluation plan, such as Scotland, while some reported more general activities.Based on WHO prevalence estimates, the current progress in decreasing tobacco use is not sufficient for countries to reach their endgame goals, especially countries with an earlier endgame goal (e.g.Ireland in 2025).Recent trends in tobacco and nicotine product market share and use patterns propose a change from exclusive cigarette use to multiple product use 56,57 .These trends could influence meeting the objectives of an endgame goal.For example, observed increases in snus use seem to impede meeting the goal of a tobaccoand nicotine-free Finland 58 .More comprehensive measures should be adopted and implemented also for other countries to meet the objectives based on the historical trends of use.Furthermore, publishing estimates of the future prevalence of different tobacco and nicotine product use by the WHO would be beneficial for countries incorporating them into their endgame goals.
There are many countries that have adopted different tobacco control measures but do not have an official endgame objective, such as Iceland, Hungary, and Ukraine.NGOs in different countries, such as Greece, Germany, Romania, and Spain, have created endgame goals or proposals, but they are not objectives of the government 59 .Supporting these and other countries that have not yet presented endgame goals, to adopt a national endgame objective would provide synergies for European countries in preventing tobacco use and accomplishing national and international tobacco endgame aims.

Strengths and limitations
Our investigation concentrated on European countries with a national endgame goal.Future studies should investigate other regions additionally.Mentions of different policy measures in each country's policy document(s) should be viewed carefully in terms of actual changes in legislation; mentioning these policies do not guarantee their further enactment and implementation.Some of the measures have been implemented after the publication of the strategies, such as plain packaging and bans on characterizing flavors in several countries.Estimating the detailed effects, such as point estimates, of the adopted policy measures in national and in European contexts, or which model of tobacco endgame is the most effective, was beyond the scope of this study.Nevertheless, our review gives a comprehensive description of the European endgame countries and their adopted strategies at one study point, providing detailed information for cross-country comparisons and further developing and assessing the tobacco endgame situation in Europe and elsewhere.

CONCLUSION
This review identified ten European countries that have adopted an official endgame goal, which usually considers a prevalence objective of use of no more than 5% by a certain year.Based on the current prevalence estimates of tobacco use, achieving the goals will be challenging unless more emphasis and specific measures are implemented to curb tobacco and nicotine product use.In some of the countries with the endgame goals, WHO FCTC and MPOWER measures have not yet been adopted fully, which also can be seen as a barrier to achieving the goals.In addition to implementing these measures, new innovative strategies and measures to target the objective of an endgame would also be essential.The current evidence on these strategies and measures is still limited and further studies are necessary, but their positive impact has been suggested.

Table 3 .
Included vulnerable groups and related actions in the current strategies among European tobacco endgame countries

Table 4 .
Prevalence (%) of tobacco, smokeless tobacco and e-cigarette use in European endgame countries In Belgium, mentions about vulnerable groups concentrated on measures of smoking cessation in different settings, such as healthcare and social care, educational institutions/ schools, and workplaces.In Sweden, supervision of tobacco and nicotine products and prevention work in schools were emphasized.
smokeless tobacco use or current e-cigarette use among adults (Tobacco control: Monitor).Available from: https://www.who.int/data/gho/data/indicators/indicator-details/GHO/gho-tobacco-control-monitor-survey-reporting-prevalence-of-smokeless-tobacco-use-or-e-cigarette-use-among-adults (accessed 1 February 2024).d The estimates for the year 2025 for Finland (13.8%) and Sweden (10.8%) in the WHO (2024) report seem incorrect based on the observed prevalence for 2022 in Panel A and in the earlier WHO (2021) report.Thus, estimates for Finland and Sweden are taken from the earlier report: WHO global report on trends in prevalence of tobacco use 2000-2025, fourth edition.Geneva: World Health Organization; 2021.Licence: CC BY-NC-SA 3.0 IGO.Available from: https://www.who.int/publications-detail-redirect/9789240039322(accessed 1 February 2024).e Data from Scotland and England are unavailable in the WHO databases, so prevalence is presented for UK as global.Tob.Prev.Cessation 2024;10(April):18 https://doi.org/10.18332/tpc/186402low socio-economic position.